this time the 2 main issues were the difficult economical situation of the Countries (people getting payed too little, taxes too high, bills no longer sustainable -especially those connected to the gas and energy industry) and the war in Ukraine.
But what really killed the "lefties" are all the restrictions and obligations about the pandemic.
Most people don't forget and forgive the longer and stricter lockdown of the entire Continent, the tons of people who lost their job, the kids who got heavily depressed because of that lockdown and the schools basically working only from remote until last Summer (so, for almost 2 full years), the fact that vaccinations were mandatory and those who didn't want to use experimental (and at this point legitimately of doubtful success) vaccines were discriminated badly (they couldn't even go to work, those who still have one, without having continuous tests, which was a torture according to them).
Add a few strictly "typical Italian" questions (all the polemics on immigrants and the safety of our cities) and our everlasting tendency to search for a new government opposite to the last that was in charge (because they always promise what they can't do...and it's the same this time, FdI and their acolytes just can't do even 10% of the things they'd like) and you have a vote like Sunday's.
by the way, in my opinion (and I underline that's just my opinion) their absolute red flags are on their view of the civil rights...surely there will be a strong constriction of those, especially for the LGBTQ+ community, on abortion and on the laws protecting working people in terms of paychecks, safety on the job, arbitrary/unfair dismissals getting a lot easier and things like that).
meanwhile I don't think they would dare to go against EU for what concerns the main foreign politics (war, relationships with the same EU and NATO and things like that), which is also a big concern for those who didn't vote for the new majority.