Depends on the kind of hilly stage. If it's several hills that are slightly high but not very steep, no. If it's lots of short but punchy hills, kind of, yes. Pure sprinters aren't going to have a chance here, the only real sprinter that's probably going to be there in terms of the top riders is Girmay, but he is quite able to deal with punchy climbs as well (I think there will be too many of them here, so he's probably not going to be in the top, but he would certainly have better chances than the likes of Cavendish, Groenewegen, Philipsen and so on). On the other hand, pure climbers probably also won't really be among the favourites, the climbs are too explosive for them.
Difference is also that it's a 275km race, whereas in the TdF you'd rarely see a stage like this go (far) over 200km, usually it stays well under that.
There's also always a big difference between a one-day race and a similar stage as part of a long stage race.